Yes. You can create custom segments and include shoppers who match one value or another within the same targeting option. For example, you can create a segment of shoppers who have an affinity for Nike or Air Jordan.
To achieve the above, you can input the two values using the same input field in the user interface:
If you wish to create a segment of Shoppers who have an affinity for Nike and Air Jordan, the same Brand Affinity rule can be selected twice:
It is currently not possible to use "or" as an operator using two different targeting options e.g "Shoppers who have an affinity for Nike or who have purchased twice".